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Vaccine Detail

Chinese S. japonicum DNA vaccine SjCTPI
Vaccine Information
  • Vaccine Name: Chinese S. japonicum DNA vaccine SjCTPI
  • Target Pathogen: Schistosoma japonicum
  • Target Disease: Schistosomiasis
  • Vaccine Ontology ID: VO_0004458
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Water buffalo
  • TPI gene engineering:
    • Type: DNA vaccine construction
    • Description: This DNA vaccine expressed triose-phosphate isomerase (SjCTPI) (Da'dara et al., 2008).
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid:
    • DNA vaccine plasmid name:
    • DNA vaccine plasmid VO ID: VO_0000024
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Water buffalo Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: Worm burdens were reduced by 41.5% and fecal miracidial hatching were reduced by 33.2% (Da'dara et al., 2008).
References
Da'dara et al., 2008: Da'dara AA, Li YS, Xiong T, Zhou J, Williams GM, McManus DP, Feng Z, Yu XL, Gray DJ, Harn DA. DNA-based vaccines protect against zoonotic schistosomiasis in water buffalo. Vaccine. 2008; 26(29-30); 3617-3625. [PubMed: 18524429].