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Vaccine Detail
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S. mansoni DNA vaccine Sm23-pcDNA encoding Sm23 |
| Vaccine Information |
- Vaccine Name: S. mansoni DNA vaccine Sm23-pcDNA encoding Sm23
- Target Pathogen: Schistosoma mansoni
- Target Disease: Schistosomiasis
- Vaccine Ontology ID: VO_0004461
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- Sm23
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pcDNA1.1/Amp expressed Schistosoma mansoni integral membrane protein Sm23 (Da'dara et al., 2001).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000360
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: The Sm23-pcDNA vaccine provided statistically significant levels of protection against challenge infection (21-44%, P<0.001-0.02) (Da'dara et al., 2001).
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| References |
Da'dara et al., 2001: Da'dara AA, Skelly PJ, Wang MM, Harn DA. Immunization with plasmid DNA encoding the integral membrane protein, Sm23, elicits a protective immune response against schistosome infection in mice. Vaccine. 2001; 20(3-4); 359-369. [PubMed: 11672898].
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