|
|
Vaccine Detail
|
S. mansoni DNA vaccine pcDNA/GPXbb encoding glutathione-S-peroxidase, GPX |
| Vaccine Information |
- Vaccine Name: S. mansoni DNA vaccine pcDNA/GPXbb encoding glutathione-S-peroxidase, GPX
- Target Pathogen: Schistosoma mansoni
- Target Disease: Schistosomiasis
- Vaccine Ontology ID: VO_0004463
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- GPX1
gene engineering:
- Type: DNA vaccine construction
- Description:
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000130
- Immunization Route: Intramuscular injection (i.m.)
|
| Host Response |
|
Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: For the regimens involving GPXbb, immunization with DNA vaccination alone resulted in protection of 44%, but the prime-boost (boost of recombinant vaccinia virus/GPXbb) resulted in 85% worm burden reduction (Shalaby et al., 2003).
|
| References |
Shalaby et al., 2003: Shalaby KA, Yin L, Thakur A, Christen L, Niles EG, LoVerde PT. Protection against Schistosoma mansoni utilizing DNA vaccination with genes encoding Cu/Zn cytosolic superoxide dismutase, signal peptide-containing superoxide dismutase and glutathione peroxidase enzymes. Vaccine. 2003; 22(1); 130-136. [PubMed: 14604580].
|
|
