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Vaccine Detail

Dengue virus DNA vaccine sABC encoding prM and E
Vaccine Information
  • Vaccine Name: Dengue virus DNA vaccine sABC encoding prM and E
  • Target Pathogen: Dengue Virus
  • Target Disease: Dengue Fever
  • Vaccine Ontology ID: VO_0004469
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Macaque
  • E protein from Dengue Virus 2 gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pMV10.1 expressed premembrane and envelope genes of each of four serotypes of dengue viruses (Raviprakash et al., 2006).
    • Detailed Gene Information: Click Here.
  • prM from Dengue virus 2 gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pMV10.1 expressed premembrane and envelope genes of each of four serotypes of dengue viruses (Raviprakash et al., 2006).
    • Detailed Gene Information: Click Here.
  • 18H6 synthetic E protein gene engineering:
    • Type: DNA vaccine construction
    • Description: This combination vaccine encoded all the proteins from all 3 vaccines (Raviprakash et al., 2006).
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid:
    • DNA vaccine plasmid name:
    • DNA vaccine plasmid VO ID: VO_0005036
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Macaque Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: When challenged with live dengue-1 or dengue-2 virus, partial protection against dengue-1 was observed. The best protection against dengue-1 viremia was demonstrated by the mixture of shuffled vaccines (sABC) out of all the vaccines tested (Raviprakash et al., 2006).
References
Raviprakash et al., 2006: Raviprakash K, Apt D, Brinkman A, Skinner C, Yang S, Dawes G, Ewing D, Wu SJ, Bass S, Punnonen J, Porter K. A chimeric tetravalent dengue DNA vaccine elicits neutralizing antibody to all four virus serotypes in rhesus macaques. Virology. 2006; 353(1); 166-173. [PubMed: 16814355].