• Vaccine Name: Dengue virus DNA vaccine D1ME encoding prM and E
• Target Pathogen: Dengue Virus
• Target Disease: Dengue Fever
• Vaccine Ontology ID: VO_0004470
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Monkey
• E from Dengue virus 1 gene engineering:
  • Type: DNA vaccine construction
  • Description: Vector pVR1012 expressed the dengue-1 pre-membrane (prM) and full-length envelope (E) genes (Raviprakash et al., 2000).
  • Detailed Gene Information: Click Here.
• prM from Dengue virus 1 gene engineering:
  • Type: DNA vaccine construction
  • Description: Vector pVR1012 (Vical Inc.) expressed the dengue-1 pre-membrane (prM) and full-length envelope (E) genes (Raviprakash et al., 2000).
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0000334
• Immunization Route: Intramuscular injection (i.m.)

Monkey Response

• Vaccine Immune Response Type: VO_0000286
• Efficacy: Four of the eight i.m.-inoculated monkeys were protected completely from developing viraemia when challenged 4 months after the last dose with homologous dengue virus. The other four monkeys had reduced viraemia compared with the control immunized monkeys. The i.d. -inoculated monkeys showed no reduction in viraemia when challenged with the virus (Raviprakash et al., 2000).