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Vaccine Detail
Dengue virus DNA vaccine D1ME encoding prM and E |
Vaccine Information |
- Vaccine Name: Dengue virus DNA vaccine D1ME encoding prM and E
- Target Pathogen: Dengue Virus
- Target Disease: Dengue Fever
- Vaccine Ontology ID: VO_0004470
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Monkey
- E from Dengue virus 1
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pVR1012 expressed the dengue-1 pre-membrane (prM) and full-length envelope (E) genes (Raviprakash et al., 2000).
- Detailed Gene Information: Click Here.
- prM from Dengue virus 1
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pVR1012 (Vical Inc.) expressed the dengue-1 pre-membrane (prM) and full-length envelope (E) genes (Raviprakash et al., 2000).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000334
- Immunization Route: Intramuscular injection (i.m.)
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Host Response |
Monkey Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: Four of the eight i.m.-inoculated monkeys were protected completely from developing viraemia when challenged 4 months after the last dose with homologous dengue virus. The other four monkeys had reduced viraemia compared with the control immunized monkeys. The i.d. -inoculated monkeys showed no reduction in viraemia when challenged with the virus (Raviprakash et al., 2000).
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References |
Raviprakash et al., 2000: Raviprakash K, Porter KR, Kochel TJ, Ewing D, Simmons M, Phillips I, Murphy GS, Weiss WR, Hayes CG. Dengue virus type 1 DNA vaccine induces protective immune responses in rhesus macaques. The Journal of general virology. 2000; 81(Pt 7); 1659-1667. [PubMed: 10859370].
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