• Vaccine Name: B. anthracis DNA vaccine pTPA-PA63
• Target Pathogen: Bacillus anthracis
• Target Disease: Anthrax
• Vaccine Ontology ID: VO_0004476
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• TPA-PA63 gene engineering:
  • Type: DNA vaccine construction
  • Description: This DNA vaccine expressed the N-terminal TPA signal, and 63 kDa mature protein (Midha and Bhatnagar, 2009).
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0005022
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccine Immune Response Type: VO_0000286
• Efficacy: Highest survival was elicited by all groups when they were challenged at week 12 and 14. Challenge was 100% fatal in control mice immunized with vector and PBS. Time-to-death analysis revealed that DNA vaccination with constructs pTPA-PA63, pPA63-LAMP1 and pTPA-PA63- LAMP1 was more protective than the native PA encoding construct (Midha and Bhatnagar, 2009).