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Vaccine Detail

B. anthracis DNA vaccine pLAMP1-PA63
Vaccine Information
  • Vaccine Name: B. anthracis DNA vaccine pLAMP1-PA63
  • Target Pathogen: Bacillus anthracis
  • Target Disease: Anthrax
  • Vaccine Ontology ID: VO_0004477
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • PA63-LAMP1 gene engineering:
    • Type: DNA vaccine construction
    • Description: This DNA vaccine expressed C-terminal LAMP1 membrane anchor and 63 kDa mature protein (Midha and Bhatnagar, 2009).
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid: pPA63-LAMP1 DNA vaccine plasmid
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Mouse Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: Highest survival was elicited by all groups when they were challenged at week 12 and 14. Challenge was 100% fatal in control mice immunized with vector and PBS. Time-to-death analysis revealed that DNA vaccination with constructs pTPA-PA63, pPA63-LAMP1 and pTPA-PA63- LAMP1 was more protective than the native PA encoding construct (Midha and Bhatnagar, 2009).
References
Midha and Bhatnagar, 2009: Midha S, Bhatnagar R. Anthrax protective antigen administered by DNA vaccination to distinct subcellular locations potentiates humoral and cellular immune responses. European journal of immunology. 2009; 39(1); 159-177. [PubMed: 19130551].