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Vaccine Detail

B. anthracis DNA vaccine pIMS-120 encoding PA
Vaccine Information
  • Vaccine Name: B. anthracis DNA vaccine pIMS-120 encoding PA
  • Target Pathogen: Bacillus anthracis
  • Target Disease: Anthrax
  • Vaccine Ontology ID: VO_0004479
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Rabbit
  • pagA gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pVAX1 expressed the mature 83 kDa full-length PA protein (without the 29 aminoacid prokaryotic secretory signal sequence) (Luxembourg et al., 2008).
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid: pVAX1 DNA vaccine plasmid
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Rabbit Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: Anthrax toxin neutralizing antibodies were also induced in rabbits immunized with electroporation with ED50 values comparable to those previously found to be protective in rabbits immunized with rPA (Luxembourg et al., 2008).
References
Luxembourg et al., 2008: Luxembourg A, Hannaman D, Nolan E, Ellefsen B, Nakamura G, Chau L, Tellez O, Little S, Bernard R. Potentiation of an anthrax DNA vaccine with electroporation. Vaccine. 2008; 26(40); 5216-5222. [PubMed: 18462850].