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Vaccine Detail

B. anthracis DNA vaccine PA83 furin
Vaccine Information
  • Vaccine Name: B. anthracis DNA vaccine PA83 furin
  • Target Pathogen: Bacillus anthracis
  • Target Disease: Anthrax
  • Vaccine Ontology ID: VO_0004481
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Rabbit
  • PA83 gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector VR1012 expressed the PA construct that was chemically synthesized (Retrogen, San Diego) to include an amino terminal human tissue plasminogen activator (hTPA) leader peptide (replacing the Bacillus leader peptide) fused to a PA83 sequence (Hermanson et al., 2004).
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid: pVR1012 DNA vaccine plasmid
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Rabbit Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: All animals receiving PA or PA plus LF pDNA vaccines were protected (Hermanson et al., 2004).
References
Hermanson et al., 2004: Hermanson G, Whitlow V, Parker S, Tonsky K, Rusalov D, Ferrari M, Lalor P, Komai M, Mere R, Bell M, Brenneman K, Mateczun A, Evans T, Kaslow D, Galloway D, Hobart P. A cationic lipid-formulated plasmid DNA vaccine confers sustained antibody-mediated protection against aerosolized anthrax spores. Proceedings of the National Academy of Sciences of the United States of America. 2004 Sep 14; 101(37); 13601-6. [PubMed: 15342913].