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Vaccine Detail

Vaccinia virus DNA vaccine B5R
Vaccine Information
  • Vaccine Name: Vaccinia virus DNA vaccine B5R
  • Target Pathogen: Vaccinia virus
  • Vaccine Ontology ID: VO_0004483
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • B5R gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pCI (Promega) expressed the complete open reading frame of B5R (Galmiche et al., 1999).
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid: pCI DNA vaccine plasmid
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Mouse Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: After challenge with lethal doses of vaccinia virus, 90% of the mice vaccinated with B5R protein were protected (Galmiche et al., 1999).
References
Galmiche et al., 1999: Galmiche MC, Goenaga J, Wittek R, Rindisbacher L. Neutralizing and protective antibodies directed against vaccinia virus envelope antigens. Virology. 1999; 254(1); 71-80. [PubMed: 9927575].