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Vaccine Detail
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Vaccinia virus DNA vaccine pWRG/L1R |
| Vaccine Information |
- Vaccine Name: Vaccinia virus DNA vaccine pWRG/L1R
- Target Pathogen: Vaccinia virus
- Vaccine Ontology ID: VO_0004484
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- L1R
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pWRG7077 expressed L1R genes from VACV (Hooper et al., 2000).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000346
- Immunization Route: Gene gun
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: Mice vaccinated with L1R alone developed neutralizing antibodies and were partially protected (Hooper et al., 2000).
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| References |
Hooper et al., 2000: Hooper JW, Custer DM, Schmaljohn CS, Schmaljohn AL. DNA vaccination with vaccinia virus L1R and A33R genes protects mice against a lethal poxvirus challenge. Virology. 2000; 266(2); 329-339. [PubMed: 10639319].
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