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Vaccine Detail

Vaccinia virus DNA vaccine tPA-D8L
Vaccine Information
  • Vaccine Name: Vaccinia virus DNA vaccine tPA-D8L
  • Target Pathogen: Vaccinia virus
  • Vaccine Ontology ID: VO_0004487
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • D8L gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pVax1TM expressed the transmembrane (TM) region and its downstream cytoplasm tail were removed from the wild type D8L gene , and a human tissue plasminogen activator (tPA) leader sequence was added to the N terminus of D8L coding gene (Sakhatskyy et al., 2006).
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid:
    • DNA vaccine plasmid name:
    • DNA vaccine plasmid VO ID: VO_0005071
  • Immunization Route: Gene gun
Host Response

Mouse Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: Individual outer membrane proteins from intracellular and extracellular virions of vaccinia virus, when delivered in the form of either DNA vaccines or recombinant protein vaccines produced from baculovirus-infected insect cells, were able to protect mice from the vaccinia virus challenge and rhesus macaques from the monkeypox virus challenge (Sakhatskyy et al., 2006).
References
Sakhatskyy et al., 2006: Sakhatskyy P, Wang S, Chou TH, Lu S. Immunogenicity and protection efficacy of monovalent and polyvalent poxvirus vaccines that include the D8 antigen. Virology. 2006; 355(2); 164-174. [PubMed: 16919703].