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Vaccine Detail

WEE virus DNA vaccine pVHX-6 encoding 26S
Vaccine Information
  • Vaccine Name: WEE virus DNA vaccine pVHX-6 encoding 26S
  • Target Pathogen: Western equine encephalomyelitis virus
  • Target Disease: Western equine encephalomyelitis (WEE)
  • Vaccine Ontology ID: VO_0004489
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • 26S gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pVAX expressed 26S structural genes of WEEV strain (Nagata et al., 2005).
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid: pVAX DNA vaccine plasmid
  • Immunization Route: Intraepidermal immunization
Host Response

Mouse Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: When the DNA vaccine plasmid, pVHX-6, was administered intraepidermally to mice, followed by challenge in a lethal mouse model, the level of protection obtained ranged from 50 to 100% amongst three strains of WEEV (Nagata et al., 2005).
References
Nagata et al., 2005: Nagata LP, Hu WG, Masri SA, Rayner GA, Schmaltz FL, Das D, Wu J, Long MC, Chan C, Proll D, Jager S, Jebailey L, Suresh MR, Wong JP. Efficacy of DNA vaccination against western equine encephalitis virus infection. Vaccine. 2005; 23(17-18); 2280-2283. [PubMed: 15755611].