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Vaccine Detail
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WEE virus DNA vaccine pVHX-6 encoding 26S |
| Vaccine Information |
- Vaccine Name: WEE virus DNA vaccine pVHX-6 encoding 26S
- Target Pathogen: Western equine encephalomyelitis virus
- Target Disease: Western equine encephalomyelitis (WEE)
- Vaccine Ontology ID: VO_0004489
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- 26S
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pVAX expressed 26S structural genes of WEEV strain (Nagata et al., 2005).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000019
- Immunization Route: Intraepidermal immunization
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: When the DNA vaccine plasmid, pVHX-6, was administered intraepidermally to mice, followed by challenge in a lethal mouse model, the level of protection obtained ranged from 50 to 100% amongst three strains of WEEV (Nagata et al., 2005).
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| References |
Nagata et al., 2005: Nagata LP, Hu WG, Masri SA, Rayner GA, Schmaltz FL, Das D, Wu J, Long MC, Chan C, Proll D, Jager S, Jebailey L, Suresh MR, Wong JP. Efficacy of DNA vaccination against western equine encephalitis virus infection. Vaccine. 2005; 23(17-18); 2280-2283. [PubMed: 15755611].
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