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Vaccine Detail

VEE virus DNA vaccine pSTU-TRDF encoding VEEV E3–E2–6K
Vaccine Information
  • Vaccine Name: VEE virus DNA vaccine pSTU-TRDF encoding VEEV E3–E2–6K
  • Target Pathogen: VEE Virus
  • Target Disease: Venezuelan equine encephalitis
  • Vaccine Ontology ID: VO_0004490
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • C-E3-E2-E1-6K gene engineering:
    • Type: DNA vaccine construction
    • Description:
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid: pJW4304 DNA vaccine plasmid
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Mouse Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: Particle-mediated epidermal delivery of a DNA vaccine encoding the E2 glycoprotein of VEEV can be boosted with a mucosally-delivered Ad-based vaccine encoding the same E2 glycoprotein, resulting in a significant increase in protection against airborne VEEV (Perkins et al., 2006).
References
Perkins et al., 2006: Perkins SD, O'Brien LM, Phillpotts RJ. Boosting with an adenovirus-based vaccine improves protective efficacy against Venezuelan equine encephalitis virus following DNA vaccination. Vaccine. 2006; 24(17); 3440-3445. [PubMed: 16527377].