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Vaccine Detail

VHSV DNA vaccine pVHS-G encoding glycoproteins
Vaccine Information
  • Vaccine Name: VHSV DNA vaccine pVHS-G encoding glycoproteins
  • Target Pathogen: Viral haemorrhagic septicaemia virus
  • Vaccine Ontology ID: VO_0004494
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Fish
  • Glycoprotein gene engineering:
    • Type: DNA vaccine construction
    • Description: The pcDNA3.1(+) vector expressed viral glycoproteins (G proteins) (Lorenzen et al., 2002).
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid: pcDNA3.1 DNA vaccine plasmid
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Rainbow trout Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: Challenge experiments revealed that immunity established shortly after vaccination was cross-protective between the VHSV and IHNV whereas no increased survival was found upon challenge with bacterial pathogens. Within two months after vaccination, the cross-protection disappeared while the specific immunity to homologous virus remained high (Lorenzen et al., 2002).
References
Lorenzen et al., 2002: Lorenzen N, Lorenzen E, Einer-Jensen K, LaPatra SE. Immunity induced shortly after DNA vaccination of rainbow trout against rhabdoviruses protects against heterologous virus but not against bacterial pathogens. Developmental and comparative immunology. 2002; 26(2); 173-179. [PubMed: 11696382].