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Vaccine Detail

M. marinum pCMV-85A
Vaccine Information
  • Vaccine Name: M. marinum pCMV-85A
  • Target Pathogen: Mycobacterium marinum
  • Vaccine Ontology ID: VO_0004496
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Fish
  • fbpA gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pcDNA 3.1 expressed Mycobacterium marinum Ag85A gene (Pasnik and Smith, 2005).
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid: pcDNA3.1 DNA vaccine plasmid
  • Immunization Route: Intraperitoneal injection (i.p.)
Host Response

Fish Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: Fish receiving the DNA vaccine developed a protective response to a live M. marinum challenge 90 days post-inoculation, as demonstrated by increased survival of vaccinated fish over control fish and by reduced splenic bacterial counts in vaccinated fish (Pasnik and Smith, 2005).
References
Pasnik and Smith, 2005: Pasnik DJ, Smith SA. Immunogenic and protective effects of a DNA vaccine for Mycobacterium marinum in fish. Veterinary immunology and immunopathology. 2005; 103(3-4); 195-206. [PubMed: 15621306].