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Vaccine Detail

Avian influenza virus DNA vaccine pH5HA
Vaccine Information
  • Vaccine Name: Avian influenza virus DNA vaccine pH5HA
  • Target Pathogen: Influenza virus
  • Target Disease: Influenza (flu)
  • Vaccine Ontology ID: VO_0004497
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse, ferret, macaque
  • HA from Influenza A virus (A/Viet Nam/1203/2004(H5N1)) gene engineering:
    • Type: DNA vaccine construction
    • Description: This DNA vaccine expressed H5 hemagglutinin (Laddy et al., 2008).
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid: pVAX DNA vaccine plasmid
  • Immunization Route: Gene gun
Host Response

Mouse Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: After challenge, protection from morbidity and mortality was seen in mice and ferrets, with significant reductions in viral shedding and disease progression seen in vaccinated animals (Laddy et al., 2008).
References
Laddy et al., 2008: Laddy DJ, Yan J, Kutzler M, Kobasa D, Kobinger GP, Khan AS, Greenhouse J, Sardesai NY, Draghia-Akli R, Weiner DB. Heterosubtypic protection against pathogenic human and avian influenza viruses via in vivo electroporation of synthetic consensus DNA antigens. PloS one. 2008; 3(6); e2517. [PubMed: 18575608].