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Vaccine Detail

Avian influenza DNA vaccine pCMV-M
Vaccine Information
  • Vaccine Name: Avian influenza DNA vaccine pCMV-M
  • Target Pathogen: Influenza virus
  • Target Disease: Influenza (flu)
  • Vaccine Ontology ID: VO_0004504
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Chicken
  • M1 gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pcDNA 3.1 expressed M1 viral proteins from an Italian H7N1 LPAI virus (Le et al., 2007).
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid: pcDNA3.1 DNA vaccine plasmid
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Chicken Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: After the homologous challenge, chickens of every vaccinated group displayed a significant decrease in cloacal shedding, whereas tracheal shedding was not significantly reduced in the protein/protein group (Le et al., 2007).
References
Le et al., 2007: Le Gall-Reculé G, Cherbonnel M, Pelotte N, Blanchard P, Morin Y, Jestin V. Importance of a prime-boost DNA/protein vaccination to protect chickens against low-pathogenic H7 avian influenza infection. Avian diseases. 2007; 51(1 Suppl); 490-494. [PubMed: 17494616].