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Vaccine Detail

PRRSV DNA vaccine pIRESorf5/IFNγ
Vaccine Information
  • Vaccine Name: PRRSV DNA vaccine pIRESorf5/IFNγ
  • Target Pathogen: Porcine respiratory and reproductive syndrome virus
  • Target Disease: Porcine Reproductive and Respiratory Syndrome (PRRS), Blue-Ear Pig Disease
  • Vaccine Ontology ID: VO_0004507
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Pig
  • ORF5 gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pIRES1neo expressed GP5, encoded by ORF5, the major envelope protein of the virus harboring neutralizing epitopes (Xue et al., 2004).
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid: pIRES1neo DNA vaccine plasmid
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Pig Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: After immunization and viral challenge, two of three pigs immunized with pIRESorf5/IFNgamma were protected from lung lesions that were present in other vaccinated and control animals (Cho and Dee, 2006).
References
Cho and Dee, 2006: Cho JG, Dee SA. Porcine reproductive and respiratory syndrome virus. Theriogenology. 2006; 66(3); 655-662. [PubMed: 16730057].
Xue et al., 2004: Xue Q, Zhao YG, Zhou YJ, Qiu HJ, Wang YF, Wu DL, Tian ZJ, Tong GZ. Immune responses of swine following DNA immunization with plasmids encoding porcine reproductive and respiratory syndrome virus ORFs 5 and 7, and porcine IL-2 and IFNgamma. Veterinary immunology and immunopathology. 2004; 102(3); 291-298. [PubMed: 15507312].