VIOLIN Logo
VO Banner
Search: for Help
About
Introduction
Statistics
VIOLIN News
Your VIOLIN
Register or Login
Submission
Tutorial
Vaccine & Components
Vaxquery
Vaxgen
VBLAST
Protegen
VirmugenDB
DNAVaxDB
CanVaxKB
Vaxjo
Vaxvec
Vevax
Huvax
Vaccine Mechanisms
Vaximmutordb
Vaxism
Vaxar
Vaccine Literature
VO-SciMiner
Litesearch
Vaxmesh
Vaxlert
Vaccine Design
Vaxign
Community Efforts
Vaccine Ontology
ICoVax 2012
ICoVax 2013
Advisory Committee
Vaccine Society
Vaxperts
VaxPub
VaxCom
VaxLaw
VaxMedia
VaxMeet
VaxFund
VaxCareer
Data Exchange
V-Utilities
VIOLINML
Help & Documents
Publications
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

Vaccine Detail

PRRSV DNA vaccine pIRESorf7/IL-2
Vaccine Information
  • Vaccine Name: PRRSV DNA vaccine pIRESorf7/IL-2
  • Target Pathogen: Porcine respiratory and reproductive syndrome virus
  • Target Disease: Porcine Reproductive and Respiratory Syndrome (PRRS), Blue-Ear Pig Disease
  • Vaccine Ontology ID: VO_0004509
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Pig
  • ORF7 gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pIRES1neo expressed N, encoded by ORF7, which forms the nucleocapsid protein of the virus, and it is likely to contain virus-specific T cell epitopes (Xue et al., 2004).
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid: pIRES1neo DNA vaccine plasmid
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Pig Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: After immunization and viral challenge, one of three pigs immunized with pIRESorf7/IL-2 was protected from lung lesions that were present in other vaccinated and control animals (Xue et al., 2004).
References
Xue et al., 2004: Xue Q, Zhao YG, Zhou YJ, Qiu HJ, Wang YF, Wu DL, Tian ZJ, Tong GZ. Immune responses of swine following DNA immunization with plasmids encoding porcine reproductive and respiratory syndrome virus ORFs 5 and 7, and porcine IL-2 and IFNgamma. Veterinary immunology and immunopathology. 2004; 102(3); 291-298. [PubMed: 15507312].