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Vaccine Detail

Hepatitis D DNA vaccine pcDNA3p27/Ad5F35p27
Vaccine Information
  • Vaccine Name: Hepatitis D DNA vaccine pcDNA3p27/Ad5F35p27
  • Target Pathogen: Hepatitis D virus
  • Vaccine Ontology ID: VO_0004529
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Woodchucks
  • p27 gene engineering:
    • Type: DNA vaccine construction
    • Description:
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid: pcDNA3 DNA vaccine plasmid
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Woodchuck Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: Immunization with DNA plasmid prime administered via gene gun and Ad5/Ad5F35-vector boost expressing HDAg conferred protection from HDV in WHV/HDV co-infection in 5 out of 7 immunized animals. The two animals with the breakthrough had a shorter HDV viremia as compared to the un-vaccinated controls (Fiedler et al., 2013)
References
Fiedler et al., 2013: Fiedler M, Kosinska A, Schumann A, Brovko O, Walker A, Lu M, Johrden L, Mayer A, Wildner O, Roggendorf M. Prime/Boost Immunization with DNA and Adenoviral Vectors Protects from Hepatitis D Virus (HDV) Infection after Simultaneous Infection with HDV and Woodchuck Hepatitis Virus. Journal of virology. 2013; ; . [PubMed: 23637419].