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Vaccine Detail
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Hepatitis D DNA vaccine pcDNA3p27/Ad5F35p27 |
| Vaccine Information |
- Vaccine Name: Hepatitis D DNA vaccine pcDNA3p27/Ad5F35p27
- Target Pathogen: Hepatitis D virus
- Vaccine Ontology ID: VO_0004529
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Woodchucks
- p27
gene engineering:
- Type: DNA vaccine construction
- Description:
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000132
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Woodchuck Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: Immunization with DNA plasmid prime administered via gene gun and Ad5/Ad5F35-vector boost expressing HDAg conferred protection from HDV in WHV/HDV co-infection in 5 out of 7 immunized animals. The two animals with the breakthrough had a shorter HDV viremia as compared to the un-vaccinated controls (Fiedler et al., 2013)
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| References |
Fiedler et al., 2013: Fiedler M, Kosinska A, Schumann A, Brovko O, Walker A, Lu M, Johrden L, Mayer A, Wildner O, Roggendorf M. Prime/Boost Immunization with DNA and Adenoviral Vectors Protects from Hepatitis D Virus (HDV) Infection after Simultaneous Infection with HDV and Woodchuck Hepatitis Virus. Journal of virology. 2013; ; . [PubMed: 23637419].
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