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Vaccine Detail

P. multocida DNA vaccine pcDNA-OMPH/OMPA
Vaccine Information
  • Vaccine Name: P. multocida DNA vaccine pcDNA-OMPH/OMPA
  • Target Pathogen: Pasteurella multocida
  • Target Disease: Pasteurellosis, fowl cholera
  • Vaccine Ontology ID: VO_0004537
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Chickens
  • OmpA gene engineering:
    • Type: DNA vaccine construction
    • Description:
    • Detailed Gene Information: Click Here.
  • ompH gene engineering:
    • Type: DNA vaccine construction
    • Description:
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid: pcDNA3.1 DNA vaccine plasmid
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Chicken Response

  • Vaccine Immune Response Type: VO_0000286
  • Immune Response: A significant increase in serum antibody levels was observed in chickens vaccinated with the fusion DNA vaccine. Additionally, the lymphocyte proliferation (SI value) and the levels of IFN-γ were both higher in chickens immunized with the fusion DNA vaccine than in those vaccinated with monovalent DNA vaccines (P<0.05) (Gong et al., 2013).
  • Efficacy: Protection provided by the fusion DNA vaccine was superior to that provided by monovalent DNA vaccines after challenging with the avian P. multocida strain CVCC474. The protective efficacy in chickens immunized three times with the fusion DNA vaccine was equivalent to the protective efficacy in chickens vaccinated once with the attenuated live vaccine (Gong et al., 2013).
References
Gong et al., 2013: Gong Q, Qu N, Niu M, Qin C, Cheng M, Sun X, Zhang A. Immune responses and protective efficacy of a novel DNA vaccine encoding outer membrane protein of avian Pasteurella multocida. Veterinary immunology and immunopathology. 2013; 152(3-4); 317-324. [PubMed: 23340446].