• Vaccine Name: M. avium DNA vaccine DNA-Av35/p2AIL12
• Target Pathogen: Mycobacterium avium
• Vaccine Ontology ID: VO_0004540
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• Antigen: M. avium 35,000 MW protein (Martin et al., 2003)
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0000276
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccine Immune Response Type: VO_0000286
• Immune Response: Co-immunization with p2AIL-12 and DNA-Av35 led to a significant increase in the number of antigen-specific IFN-gamma secreting cells and total amount of IFN-gamma released, but a concomitant fall in the antibody response to the 35000 MW protein (Martin et al., 2003).
• Efficacy: Immunization with DNA-Av35 resulted in significant protective immunity against M. avium infection with a 2-log10 reduction in the M. avium load in the spleen (P < 0.001). The addition of p2AIL12 to the DNA-Av35 vaccine significantly increased the level of protection in both the spleen (P < 0.005) and liver (P < 0.01), with a further reduction in the bacterial load of about 1-log10 (Martin et al., 2003).