• Vaccine Name: E. tarda DNA vaccine pCE6
• Target Pathogen: Edwardsiella tarda
• Vaccine Ontology ID: VO_0004557
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Japanese flounder
• Antigen: FliC-Eta6 fusion protein from E. tarda TX1 (Jiao et al., 2009)
• fliC gene engineering:
  • Type: DNA vaccine construction
  • Description:
  • Detailed Gene Information: Click Here.
• eta6 gene engineering:
  • Type: DNA vaccine construction
  • Description:
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0000992
• Immunization Route: Intramuscular injection (i.m.)

Fish Response

• Vaccine Immune Response Type: VO_0003057
• Efficacy: Upon exposure to TX1 challenge, the cumulative mortalities of the pCE6-, pCN3-, and PBS-vaccinated fish were 25%, 90%, and 95%, respectively. Therefore, compared to vaccination with pCN3, vaccination with pCE6 produced a RPS of 72%, which is significantly higher than that produced by pEta6 (Jiao et al., 2009).