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Vaccine Detail
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E. tarda DNA vaccine pCEsa1 |
| Vaccine Information |
- Vaccine Name: E. tarda DNA vaccine pCEsa1
- Target Pathogen: Edwardsiella tarda
- Vaccine Ontology ID: VO_0004558
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Japanese flounder
- Antigen: Esa1 from E. tarda TX1 (Sun et al., 2011)
- esa1
gene engineering:
- Type: DNA vaccine construction
- Description:
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000992
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Fish Response
- Vaccine Immune Response Type: VO_0003057
- Efficacy: The accumulated mortalities of pCEsa1-, pCN3-, and PBS-vaccinated fish were 20%, 76%, and 80%, respectively. Hence, compared to PBS-vaccinated fish, pCEsa1-vaccinated fish were significantly (P < 0.05) protected, with a RPS of 75% (Sun et al., 2011).
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| References |
Sun et al., 2011: Sun Y, Liu CS, Sun L. Construction and analysis of the immune effect of an Edwardsiella tarda DNA vaccine encoding a D15-like surface antigen. Fish & shellfish immunology. 2011; 30(1); 273-279. [PubMed: 21059395].
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