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Vaccine Detail

Leptospira interrogans DNA vaccine ompL1-pcDNA3.1(+)
Vaccine Information
  • Vaccine Name: Leptospira interrogans DNA vaccine ompL1-pcDNA3.1(+)
  • Target Pathogen: Leptospira spp.
  • Target Disease: Leptospirosis
  • Vaccine Ontology ID: VO_0004562
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Hamsters
  • ompL1 gene engineering:
    • Type: DNA vaccine construction
    • Description:
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid: pcDNA3.1 DNA vaccine plasmid
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Hamster Response

  • Vaccine Immune Response Type: VO_0003057
  • Efficacy: The vaccine was shown to confer the delay in the death time and reduced morbidity in the vaccinated animals when compared to animals immunized with the plasmid alone or PBS. Hamsters of group 2 (mock) and group 3 (positive leptospirosis) were all dead between days 5 and 6 post-challenge. For the vaccinated group, two hamsters were dead on day 9, one each died on days 11 and 18, respectively. Two hamsters survived the lethal Leptospira challenge until day 21 when they were sacrificed (Maneewatch et al., 2007).
References
Maneewatch et al., 2007: Maneewatch S, Tapchaisri P, Sakolvaree Y, Klaysing B, Tongtawe P, Chaisri U, Songserm T, Wongratanacheewin S, Srimanote P, Chongsa-nguanz M, Chaicumpa W. OmpL1 DNA vaccine cross-protects against heterologous Leptospira spp. challenge. Asian Pacific journal of allergy and immunology / launched by the Allergy and Immunology Society of Thailand. 2007; 25(1); 75-82. [PubMed: 17891923].