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Vaccine Detail

Leptospira interrogans DNA vaccine pTARGET/ LigBrep
Vaccine Information
  • Vaccine Name: Leptospira interrogans DNA vaccine pTARGET/ LigBrep
  • Target Pathogen: Leptospira spp.
  • Target Disease: Leptospirosis
  • Vaccine Ontology ID: VO_0004563
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Hamsters
  • ligB gene engineering:
    • Type: DNA vaccine construction
    • Description:
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid: pTARGET DNA vaccine plasmid
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Hamster Response

  • Vaccine Immune Response Type: VO_0003057
  • Immune Response: The vaccine induced an IgG antibody response and, additionally, conferred sterilizing immunity in 80% of the surviving animals (Forster et al., 2013).
  • Efficacy: Immunization with a DNA vaccine encoding LigBrep resulted in the survival of 5/8 (62.5%) hamsters against lethal infection (P < 0.05). None of the control hamsters or animals immunized with the other vaccine preparations survived (Forster et al., 2013).
References
Forster et al., 2013: Forster KM, Hartwig DD, Seixas FK, Bacelo KL, Amaral M, Hartleben CP, Dellagostin OA. A Conserved Region of Leptospiral Immunoglobulin-Like A and B Proteins as a DNA Vaccine Elicits a Prophylactic Immune Response against Leptospirosis. Clinical and vaccine immunology : CVI. 2013; 20(5); 725-731. [PubMed: 23486420].