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Vaccine Detail
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Y. pestis DNA vaccine YscF-2 |
| Vaccine Information |
- Vaccine Name: Y. pestis DNA vaccine YscF-2
- Target Pathogen: Yersinia pestis
- Target Disease: Plague
- Vaccine Ontology ID: VO_0004573
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- YscF from Y. pestis KIM 10
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pJW4303 had two copies of yscF gene in tandem (Wang et al., 2008).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000276
- Immunization Route: Gene gun
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0003057
- Efficacy: In the YscF-2 immunized group, 60% of mice survived the intranasal challenge, which was significant as compared to either wt.YscF or tPA.YscF DNA vaccines according to Fisher's exact test (p < 0.05) (Wang et al., 2008).
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| References |
Wang et al., 2008: Wang S, Joshi S, Mboudjeka I, Liu F, Ling T, Goguen JD, Lu S. Relative immunogenicity and protection potential of candidate Yersinia Pestis antigens against lethal mucosal plague challenge in Balb/C mice. Vaccine. 2008; 26(13); 1664-1674. [PubMed: 18291562].
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