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Vaccine Detail

RHDV DNA vaccine pcDNA-VP60
Vaccine Information
  • Vaccine Name: RHDV DNA vaccine pcDNA-VP60
  • Target Pathogen: Rabbit hemorrhagic disease virus
  • Target Disease: Rabbit hemorrhagic disease
  • Vaccine Ontology ID: VO_0004577
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Rabbits
  • ORF1 gene engineering:
    • Type: DNA vaccine construction
    • Description:
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid: pcDNA3.1 DNA vaccine plasmid
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Rabbit Response

  • Vaccine Immune Response Type: VO_0003057
  • Immune Response: In all cases, the rabbits immunized with pcDNA-VP60 developed high level of RHDV-specific antibodies and cellular immune response (Yuan et al., 2013).
  • Efficacy: The rabbits inoculated with PBS and pcDNA3.1(+) were not protected from the RHDV challenge and developed high fever and oronasal hemorrhage, and died within two days after challenge as a consequence of the viral infection. All pcDNA-VP60 and RHDV inactive vaccine vaccinated rabbits survived (Yuan et al., 2013).
References
Yuan et al., 2013: Yuan D, Qu L, Liu J, Guo D, Jiang Q, Lin H, Si C. DNA vaccination with a gene encoding VP60 elicited protective immunity against rabbit hemorrhagic disease virus. Veterinary microbiology. 2013; 164(1-2); 1-8. [PubMed: 23419819].