• Vaccine Name: HSV 2 DNA vaccine pVAX–HSV–2gD–Hsp70
• Target Pathogen: Herpes simplex virus type 1 and 2
• Target Disease: Herpes
• Vaccine Ontology ID: VO_0004578
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• Antigen: HSV–2gD gene fragment and Tubercle bacillus Hsp70 gene (Fan and Yang, 2010)
• gD gene engineering:
  • Type: DNA vaccine construction
  • Description:
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0000019
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccine Immune Response Type: VO_0003057
• Immune Response: The IgG response in serum in vaccinated mice with pVAX–HSV–2gD and pVAX–HSV–2gD–Hsp70 differed significantly (P < 0.05) from those in immunized mice with pVAX and pVAX–Hsp70, which did not generate antibody levels above background. The highest IgG concentration was observed in serum of mice immunized with pVAX–HSV–2gD–Hsp70, which showed significant differences compared with the other three groups (P < 0.05) (Fan and Yang, 2010).
• Efficacy: Eight of the animals (8/10) have survived in group pVAX–HSV–2gD–Hsp70. Only one survived in the pVAX and pVAX–Hsp70 groups (Fan and Yang, 2010).