|
|
Vaccine Detail
|
HRSV DNA vaccine pND-G |
| Vaccine Information |
- Vaccine Name: HRSV DNA vaccine pND-G
- Target Pathogen: Human Respiratory Syncytial Virus
- Target Disease: Respiratory tract disease
- Vaccine Ontology ID: VO_0004580
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- G
gene engineering:
- Type: DNA vaccine construction
- Description:
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000285
- Immunization Route: Intradermal injection (i.d.)
|
| Host Response |
|
Mouse Response
- Vaccine Immune Response Type: VO_0003057
- Efficacy: Immunization with the pND-G vaccine significantly inhibited the RSV induced increase in airway responsiveness to methacholine (Mch) (n=3 separate experiments; 12 mice per group) (P<0.05 versus RSV). The concentration of Mch required to induce a 200% increase in airway responsiveness (PC200) was significantly greater in RSV infected mice who had received the pND-G vaccine compared to RSV infected mice who had not received the vaccine (21.5 mg/ml Mch versus 7.2 mg/ml Mch) (P<0.05) (Miller et al., 2002).
|
| References |
Miller et al., 2002: Miller M, Cho JY, Baek KJ, Castaneda D, Nayar J, Rodriguez M, Roman M, Raz E, Broide DH. Plasmid DNA encoding the respiratory syncytial virus G protein protects against RSV-induced airway hyperresponsiveness. Vaccine. 2002; 20(23-24); 3023-3033. [PubMed: 12126916].
|
|
