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Vaccine Detail
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SHIV DNA vaccine encoding env and gag |
| Vaccine Information |
- Vaccine Name: SHIV DNA vaccine encoding env and gag
- Target Pathogen: Human Immunodeficiency Virus
- Target Disease: Acquired Immunodeficiency Syndrome (AIDS)
- Vaccine Ontology ID: VO_0004596
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Rhesus macaques
- env
gene engineering:
- Type: DNA vaccine construction
- Description:
- Detailed Gene Information: Click Here.
- env
gene engineering:
- Type: DNA vaccine construction
- Description:
- Detailed Gene Information: Click Here.
- env
gene engineering:
- Type: DNA vaccine construction
- Description:
- Detailed Gene Information: Click Here.
- env
gene engineering:
- Type: DNA vaccine construction
- Description:
- Detailed Gene Information: Click Here.
- gag from HIV-1 vector pNL4-3
gene engineering:
- Type: DNA vaccine construction
- Description:
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0005071
- Immunization Route: Gene gun
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| Host Response |
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Macaque Response
- Vaccine Immune Response Type: VO_0003057
- Efficacy: The immune response elicited by the multivalent DNA prime/protein boost vaccine was able to protect macaques from rectal challenge with SHIV-Ba-L isolate. This polyvalent vaccine formulation was able to confer protection in four out of six animals against SHIV-Ba-L and significantly reduced plasma viremia in the two remaining animals (Pal et al., 2006).
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| References |
Pal et al., 2006: Pal R, Kalyanaraman VS, Nair BC, Whitney S, Keen T, Hocker L, Hudacik L, Rose N, Mboudjeka I, Shen S, Wu-Chou TH, Montefiori D, Mascola J, Markham P, Lu S. Immunization of rhesus macaques with a polyvalent DNA prime/protein boost human immunodeficiency virus type 1 vaccine elicits protective antibody response against simian human immunodeficiency virus of R5 phenotype. Virology. 2006; 348(2); 341-353. [PubMed: 16460776].
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