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Vaccine Detail

Aeromonas hydrophila LSA34 vector vaccine WED/pUTDgap
Vaccine Information
  • Vaccine Name: Aeromonas hydrophila LSA34 vector vaccine WED/pUTDgap
  • Target Pathogen: Aeromonas hydrophila
  • Vaccine Ontology ID: VO_0004606
  • Type: Recombinant vector vaccine
  • Status: Research
  • Antigen: The protective antigen GAPDH from the fish pathogen A. hydrophila, encoded by the gene gapA34 (Mu et al., 2011).
  • Vector: Edwardsiella tarda EIB202 vaccine vector
  • Preparation: The gapA34 gene was introduced into P(dps) and transformed into live, attenuated E. tarda strain EIB202 (Mu et al., 2011).
  • Immunization Route: Intramuscular injection (i.m.)
  • Description: A. hydrophila is a common fish pathogen, so in order to create a vaccine against this pathogen, the gapA34 gene of A. hydrophila was expressed in the bacterial vector E. tarda strain EIB202, and it was shown to increase survival of vaccinated fish (Mu et al., 2011).
Host Response

Fish Response

  • Host Strain: Turbot (Scophtalmus maximus)
  • Vaccine Immune Response Type: VO_0000287
  • Efficacy: Over 60% of the fish vaccinated with the WED/pUTDgap vector vaccine survived the A. hydrophila challenge (Mu et al., 2011).
  • Description: The P(dps) promoter--which was chosen due to its high transcription activity-- was shown to elicit survival in turbot, meaning that it has the potential to be an important part of bacterial vaccine vector application (Mu et al., 2011) .
References
Mu et al., 2011: Mu W, Guan L, Yan Y, Liu Q, Zhang Y. A novel in vivo inducible expression system in Edwardsiella tarda for potential application in bacterial polyvalence vaccine. Fish & shellfish immunology. 2011; 31(6); 1097-1105. [PubMed: 21964456].