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Vaccine Detail

rSPV-PCV2-cap
Vaccine Information
  • Vaccine Name: rSPV-PCV2-cap
  • Target Pathogen: Porcine circovirus 2
  • Target Disease: Postweaning multisystemic wasting syndrome
  • Product Name: recombinant swinepox virus expressing PCV2 capsid protein
  • Vaccine Ontology ID: VO_0004619
  • Type: Recombinant vector vaccine
  • Status: Research
  • Host Species for Licensed Use: Baboon
  • Antigen: PCV2 capsid
  • Preparation: Recombinant swinepox virus expressing capsid protein (rSPV-cap) (Lin et al., 2012).
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Pig Response

  • Vaccination Protocol: Pigs were immunized with rSPV-cap, wild type SPV (wtSPV; negative control), or PBS (challenge control) (Lin et al., 2012).
  • Vaccine Immune Response Type: VO_0003057
  • Challenge Protocol: Vaccinated pigs were challenged with PCV2 (Lin et al., 2012).
  • Efficacy: After inoculation with PCV2, pigs in the rSPV-cap immunized group showed significantly higher average daily weight gain (ADG) and shorter fever duration compared with the wtSPV treated group. The results suggested that the recombinant rSPV-cap provided pigs with significant protection from PCV2-associated disease (Lin et al., 2012).
References
Lin et al., 2012: Lin HX, Ma Z, Fan HJ, Lu CP. Construction and immunogenicity of recombinant swinepox virus expressing capsid protein of PCV2. Vaccine. 2012; 30(44); 6307-6313. [PubMed: 22884664].