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Vaccine Detail
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HS93Tox-/pIG-T1K |
| Vaccine Information |
- Vaccine Name: HS93Tox-/pIG-T1K
- Target Pathogen: Actinobacillus pleuropneumoniae
- Target Disease: porcine pleuropneumonia
- Vaccine Ontology ID: VO_0004637
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Baboon
- apxIA
gene engineering:
- Type: Recombinant vector construction
- Description: HS93Tox-/pIG-T1K, expresses the Apx structural protein in a non-activated form (Prideaux et al., 1998).
- Detailed Gene Information: Click Here.
- Vector:
- Preparation: HS93Tox-/pIG-T1K, expresses the Apx structural protein in a non-activated form (Prideaux et al., 1998).
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccination Protocol: Mice were vaccinated with alive strain of HS93Tox-/pIG-T1K (Prideaux et al., 1998).
- Vaccine Immune Response Type: VO_0003057
- Challenge Protocol: Mice were challenged with a wild-type serovar 7, and a serovar 1 strain (Prideaux et al., 1998).
- Efficacy: Live vaccination of mice with HS93Tox-/pIG-T1K offered protection against homologous wild-type serovar 7 challenge, and also heterologous challenge with a serovar 1 strain (Prideaux et al., 1998).
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| References |
Prideaux et al., 1998: Prideaux CT, Pierce L, Krywult J, Hodgson AL. Protection of mice against challenge with homologous and heterologous serovars of Actinobacillus pleuropneumoniae after live vaccination. Current microbiology. 1998; 37(5); 324-332. [PubMed: 9767712].
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