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Vaccine Detail

HS93Tox-/pIG-T1K
Vaccine Information
  • Vaccine Name: HS93Tox-/pIG-T1K
  • Target Pathogen: Actinobacillus pleuropneumoniae
  • Target Disease: porcine pleuropneumonia
  • Vaccine Ontology ID: VO_0004637
  • Type: Recombinant vector vaccine
  • Status: Research
  • Host Species for Licensed Use: Baboon
  • apxIA gene engineering:
    • Type: Recombinant vector construction
    • Description: HS93Tox-/pIG-T1K, expresses the Apx structural protein in a non-activated form (Prideaux et al., 1998).
    • Detailed Gene Information: Click Here.
  • Vector: Actinobacillus pleuropneumoniae HS93Tox vaccine vector
  • Preparation: HS93Tox-/pIG-T1K, expresses the Apx structural protein in a non-activated form (Prideaux et al., 1998).
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Mouse Response

  • Vaccination Protocol: Mice were vaccinated with alive strain of HS93Tox-/pIG-T1K (Prideaux et al., 1998).
  • Vaccine Immune Response Type: VO_0003057
  • Challenge Protocol: Mice were challenged with a wild-type serovar 7, and a serovar 1 strain (Prideaux et al., 1998).
  • Efficacy: Live vaccination of mice with HS93Tox-/pIG-T1K offered protection against homologous wild-type serovar 7 challenge, and also heterologous challenge with a serovar 1 strain (Prideaux et al., 1998).
References
Prideaux et al., 1998: Prideaux CT, Pierce L, Krywult J, Hodgson AL. Protection of mice against challenge with homologous and heterologous serovars of Actinobacillus pleuropneumoniae after live vaccination. Current microbiology. 1998; 37(5); 324-332. [PubMed: 9767712].