• Vaccine Name: BV-H5/H7/H9
• Target Pathogen: Influenza virus
• Target Disease: Influenza (flu)
• Vaccine Ontology ID: VO_0004654
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Baboon
• HA from Influenza A virus (A/Viet Nam/1203/2004(H5N1)) gene engineering:
  • Type: Recombinant vector construction
  • Description: A recombinant virus-like particle (VLP) that co-localizes hemagglutinin (HA) proteins derived from H5N1, H7N2, and H9N2 viruses (Tretyakova et al., 2013).
  • Detailed Gene Information: Click Here.
• HA gene engineering:
  • Type: Recombinant vector construction
  • Description: A recombinant virus-like particle (VLP) that co-localizes hemagglutinin (HA) proteins derived from H5N1, H7N2, and H9N2 viruses (Tretyakova et al., 2013).
  • Detailed Gene Information: Click Here.
• Vector:
  • Vector name:
  • VO vector ID: VO_0001084
• Preparation: A baculovirus vector co-expressing the H5, H7, and H9 genes from A/Viet Nam/1203/2004 (H5N1), A/New York/107/2003 (H7N2) and A/Hong Kong/33982/2009 (H9N2) viruses, respectively, as well as neuraminidase (NA) and matrix (M1) genes from A/Puerto Rico/8/1934 (H1N1) virus (Tretyakova et al., 2013).
• Immunization Route: Intramuscular injection (i.m.)

Ferret Response

• Vaccination Protocol: Ferrets received two vaccinations i.n. of the H5/H7/H9 triple-subtype VLPs and control animals received PBS in place of vaccine (Tretyakova et al., 2013).
• Vaccine Immune Response Type: VO_0003057
• Challenge Protocol: The ferrets were challenged with 10^6 EID50 challenges with H7N2 or H9N2 (Tretyakova et al., 2013).
• Efficacy: Intranasal vaccination of ferrets with the VLPs resulted in induction of serum antibody responses and efficient protection against experimental challenges with H5N1, H7N2, and H9N2 viruses (Tretyakova et al., 2013).