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Vaccine Detail

rBCG -Stx2B (Escherichia coli )
Vaccine Information
  • Vaccine Name: rBCG -Stx2B (Escherichia coli )
  • Target Pathogen: Escherichia coli
  • Target Disease: Hemorrhagic colitis
  • Vaccine Ontology ID: VO_0004657
  • Type: Recombinant vector vaccine
  • Status: Research
  • Host Species for Licensed Use: Baboon
  • StxB2 gene engineering:
    • Type: Recombinant vector construction
    • Description: A novel vaccine against Shiga toxin (Stx)-producing Escherichia coli (STEC) infection using a recombinant Mycobacterium bovis BCG (rBCG) system expressing the Stx2 B subunit (Stx2B) (Fujii et al., 2012).
    • Detailed Gene Information: Click Here.
  • Vector: BCG vaccine vector
  • Preparation: rBCG expressing the Stx2 B subunit (Stx2B) (Fujii et al., 2012).
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Mouse Response

  • Vaccination Protocol: The mice were given Two intraperitoneal vaccinations of rBCG -Stx2B (Fujii et al., 2012).
  • Vaccine Immune Response Type: VO_0003057
  • Challenge Protocol: The mice were orally challenged with 103 CFU of STEC strain B2F1 (O91: H21) (Fujii et al., 2012).
  • Efficacy: The immunized mice survived statistically significantly longer than the nonvaccinated mice (Fujii et al., 2012).
References
Fujii et al., 2012: Fujii J, Naito M, Yutsudo T, Matsumoto S, Heatherly DP, Yamada T, Kobayashi H, Yoshida S, Obrig T. Protection by a recombinant Mycobacterium bovis Bacillus Calmette-Guerin vaccine expressing Shiga toxin 2 B subunit against Shiga toxin-producing Escherichia coli in mice. Clinical and vaccine immunology : CVI. 2012; 19(12); 1932-1937. [PubMed: 23035176].