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Vaccine Detail
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VSV*ΔG-H5 (H5N1) |
| Vaccine Information |
- Vaccine Name: VSV*ΔG-H5 (H5N1)
- Target Pathogen: Influenza virus
- Target Disease: Influenza (flu)
- Vaccine Ontology ID: VO_0004659
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Baboon
- HA
gene engineering:
- Type: Recombinant vector construction
- Description:
- Detailed Gene Information: Click Here.
- Vector:
- Preparation: A recombinant vesicular stomatitis virus (VSV) vector was used to express HA of subtype H5 (Halbherr et al., 2013).
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Chicken Response
- Vaccine Immune Response Type: VO_0003057
- Efficacy: Vaccination of chickens with a single intramuscular dose of 2×10⁸ infectious replicon particles without adjuvant conferred complete protection from lethal H5N1 infection (Halbherr et al., 2013).
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| References |
Halbherr et al., 2013: Halbherr SJ, Brostoff T, Tippenhauer M, Locher S, Berger Rentsch M, Zimmer G. Vaccination with recombinant RNA replicon particles protects chickens from H5N1 highly pathogenic avian influenza virus. PloS one. 2013; 8(6); e66059. [PubMed: 23762463].
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