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Vaccine Detail

SL3261-P. aeruginosa serogroup O11 O antigen
Vaccine Information
  • Vaccine Name: SL3261-P. aeruginosa serogroup O11 O antigen
  • Target Pathogen: Pseudomonas aeruginosa
  • Target Disease: Pseudomonas aeruginosa infection
  • Vaccine Ontology ID: VO_0004674
  • Type: Recombinant vector vaccine
  • Status: Research
  • Host Species for Licensed Use: Baboon
  • Vector: Salmonella typhimurium SL3261 vaccine vector
  • Preparation: Attenuated Salmonella enterica serovar Typhimurium SL3261 expressing P. aeruginosa serogroup O11 O antigen (DiGiandomenico et al., 2004).
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Mouse Response

  • Vaccination Protocol: For oral vaccination, mice were fed 100 μl of either PBS or the Salmonella vector and vaccine strains (1 × 109 to 5 × 109 CFU) by intragastric gavage. Oral inoculation was repeated once per week for a total of 4 weeks. For i.p. vaccination, mice were inoculated with a single dose of either PBS or each Salmonella strain (106 CFU) (DiGiandomenico et al., 2004).
  • Vaccine Immune Response Type: VO_0003057
  • Challenge Protocol: Mice were challenged with P. aeruginosa strains 9882-80 (serogroup O11) and 6294 (serogroup O6) (DiGiandomenico et al., 2004).
  • Efficacy: Orally vaccinated mice with an O11 strain (9882-80) at 6 and 12 times the 50% lethal dose showed increased survival in mice that received the vaccine compared to phosphate-buffered saline (PBS)- and vector-treated controls; no difference in survival was seen with a heterologous strain, 6294 (serogroup O6). In addition, significant protection against 9882-80 was not observed in i.p. vaccinated animals (DiGiandomenico et al., 2004).
References