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Vaccine Detail

SL3261 expressing streptococcal M protein
Vaccine Information
  • Vaccine Name: SL3261 expressing streptococcal M protein
  • Target Pathogen: Streptococcus pyogenes
  • Target Disease: Group A streptococcal infections, Strep throat, Scarlet fever
  • Vaccine Ontology ID: VO_0004676
  • Type: Recombinant vector vaccine
  • Status: Research
  • Host Species for Licensed Use: Baboon
  • Vector: Salmonella typhimurium SL3261 vaccine vector
  • Preparation: The aroA strain of S. typhimurium SL3261 was transformed with a low-copy plasmid vector pMK207, which contains the cloned gene spm5 encoding streptococcal M protein, the major virulence factor of these organisms (Poirier et al., 1988).
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Mouse Response

  • Vaccination Protocol: Mice were immunized orally with the pMK207-transformed Salmonella SL3261 (Poirier et al., 1988).
    .
  • Vaccine Immune Response Type: VO_0003057
  • Challenge Protocol: Immunized and control mice were challenged intraperitoneally with either the homologous M5 or heterologous M24 streptococci, or with wild-type S typhimurium SL1344 (Poirier et al., 1988).
  • Efficacy: The orally immunized mice were completely protected against both intranasal and intraperitoneal challenge infections with virulent S. typhimurium SL1344 or M5 streptococci (Poirier et al., 1988).
References
Poirier et al., 1988: Poirier TP, Kehoe MA, Beachey EH. Protective immunity evoked by oral administration of attenuated aroA Salmonella typhimurium expressing cloned streptococcal M protein. The Journal of experimental medicine. 1988; 168(1); 25-32. [PubMed: 3294331].