• Vaccine Name: Schmidt-Ruppin Rous sarcoma virus-H7 (H7N7)
• Target Pathogen: Influenza virus
• Target Disease: Influenza (flu)
• Vaccine Ontology ID: VO_0004677
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Baboon
• HA gene engineering:
  • Type: Recombinant vector construction
  • Description: An influenza virus hemagglutinin gene, H7, has been expressed in a replication-competent Schmidt-Ruppin Rous sarcoma virus-derived vector (Hunt et al., 1988).
  • Detailed Gene Information: Click Here.
• Vector:
  • Vector name:
  • VO vector ID: VO_0001102
  • Description: (Hunt et al., 1988)
• Preparation: Recombinant baculovirus expressing the hemagglutinin gene of the influenza virus, A/PR/8/34 (H1N1), under the control of the chicken beta-actin promoter, (Hunt et al., 1988).
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccination Protocol: The baculoviruses (AcCAG-HA or AcNPV) (1.1 × 10^8 PFU/mouse) were inoculated twice, 2 wk apart, into the abdominal epidermis of the mice (Hunt et al., 1988).
• Vaccine Immune Response Type: VO_0003057
• Challenge Protocol: A lethal challenge with influenza virus consisting of 5.6 × 10^5 PFU of mouse-adapted A/PR/8/34 influenza virus (100 LD50) in 50 μl of saline was administered intranasally 3 wk after the second immunization (Hunt et al., 1988).
• Efficacy: However, protection from a lethal challenge of the influenza virus was only achieved by intranasal immunization of the recombinant baculovirus. Surprisingly, sufficient protection from the lethal influenza challenge was also observed in mice inoculated intranasally with a wild-type baculovirus, as evaluated by reductions in the virus titer, inflammatory cytokine production, and pulmonary consolidations (Hunt et al., 1988).