• Vaccine Name: rAPMV3-F (newcastle disease)
• Target Pathogen: Newcastle disease virus
• Target Disease: Newcastle disease
• Vaccine Ontology ID: VO_0004684
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Baboon
• F fusion protein gene engineering:
  • Type: Recombinant protein preparation
  • Description: Recombinant viruses, rAPMV3-F and rAPMV3-HN, were generated expressing the NDV fusion (F) and hemagglutinin-neuraminidase (HN) proteins (Kumar et al., 2011).
  • Detailed Gene Information: Click Here.
• HN hemagglutinin-neuraminidase gene engineering:
  • Type: Recombinant vector construction
  • Description: Recombinant viruses, rAPMV3-F and rAPMV3-HN, were generated expressing the NDV fusion (F) and hemagglutinin-neuraminidase (HN) proteins (Kumar et al., 2011).
  • Detailed Gene Information: Click Here.
• Vector:
  • Vector name:
  • VO vector ID: VO_0001045
• Preparation: Recombinant virus, rAPMV3-F generated expressinv the NDV fusion protein (Kumar et al., 2011).
• Immunization Route: Intramuscular injection (i.m.)

Chicken Response

• Vaccination Protocol: 2-week-old chickens were immunized by the oculonasal route in order to evaluate the contribution of each protein to the induction of NDV-specific neutralizing antibodies and protective immunity (Kumar et al., 2011).
• Vaccine Immune Response Type: VO_0003057
• Challenge Protocol: The immunized birds were challenged 21 days after vaccination with virulent NDV via the oculonasal, intramuscular, or intravenous route (Kumar et al., 2011).
• Efficacy: With oculonasal or intramuscular challenge, all three recombinant viruses (rAPMV3, rAPMV3-F, and rAPMV3-HN) were protective, while all unvaccinated birds succumbed to death. However, with intravenous challenge, birds immunized with rAPMV3 were not protected, whereas birds immunized with rAPMV3-F alone or in combination with rAPMV3-HN were completely protected, and birds immunized with rAPMV3-HN alone were partially protected. These results indicate that the NDV F and HN proteins are independent neutralization and protective antigens, but the contribution by F is greater (Kumar et al., 2011).