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Vaccine Detail

HSVT[VP7/6/2]
Vaccine Information
  • Vaccine Name: HSVT[VP7/6/2]
  • Target Pathogen: Rotavirus
  • Target Disease: Gastroenteritis
  • Vaccine Ontology ID: VO_0004687
  • Type: Recombinant vector vaccine
  • Status: Research
  • Host Species for Licensed Use: Baboon
  • VP2 gene engineering:
    • Type: Recombinant vector construction
    • Description: HSV-1 amplicon vectors encoding individual or multiple structural RV proteins from a polycistronic transgene cassette in mammalian cells (Laimbacher et al., 2012).
    • Detailed Gene Information: Click Here.
  • VP6 gene engineering:
    • Type: Recombinant vector construction
    • Description: HSV-1 amplicon vectors encoding individual or multiple structural RV proteins from a polycistronic transgene cassette in mammalian cells (Laimbacher et al., 2012).
    • Detailed Gene Information: Click Here.
  • VP7 gene engineering:
    • Type: Recombinant vector construction
    • Description: HSV-1 amplicon vectors encoding individual or multiple structural RV proteins from a polycistronic transgene cassette in mammalian cells (Laimbacher et al., 2012).
    • Detailed Gene Information: Click Here.
  • Vector: Herpes simplex virus vaccine 1 vector
  • Preparation: Herpes simplex virus type 1 (HSV-1) amplicon vectors were constructed to coexpress the rotavirus (RV) structural genes VP2, VP6, and VP7 (Laimbacher et al., 2012).
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Mouse Response

  • Vaccination Protocol: intramuscular injection of mice with the amplicon vectors as a two-dose regimen without adjuvants (Laimbacher et al., 2012).
  • Vaccine Immune Response Type: VO_0001030
  • Challenge Protocol: Immunized mice were challenged with live wild-type (wt) rotavirus infection (Laimbacher et al., 2012).
  • Efficacy: Immunized mice were partially protected at the mucosal level (Laimbacher et al., 2012).
References
Laimbacher et al., 2012: Laimbacher AS, Esteban LE, Castello AA, Abdusetir Cerfoglio JC, Arg├╝elles MH, Glikmann G, D'Antuono A, Mattion N, Berois M, Arbiza J, Hilbe M, Schraner EM, Seyffert M, Dresch C, Epstein AL, Ackermann M, Fraefel C. HSV-1 amplicon vectors launch the production of heterologous rotavirus-like particles and induce rotavirus-specific immune responses in mice. Molecular therapy : the journal of the American Society of Gene Therapy. 2012; 20(9); 1810-1820. [PubMed: 22713696].