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Vaccine Detail

RCN-HA (H5N1)
Vaccine Information
  • Vaccine Name: RCN-HA (H5N1)
  • Target Pathogen: Influenza virus
  • Target Disease: Influenza (flu)
  • Vaccine Ontology ID: VO_0004691
  • Type: Recombinant vector vaccine
  • Status: Research
  • Host Species for Licensed Use: Mouse
  • Vector:
  • Preparation: Recombinant raccoonpox (RCN) virus acted as a vector to express the hemagglutinin (HA) from H5N1 viruses (Kingstad-Bakke et al., 2012).
  • Immunization Route: Intradermal injection (i.d.)
Host Response

Mouse Response

  • Vaccine Immune Response Type: VO_0003057
  • Efficacy: RCN-HA provided strong protection when administered intradermally (ID), but not intranasally (IN) (Kingstad-Bakke et al., 2012).
References
Kingstad-Bakke et al., 2012: Kingstad-Bakke B, Brewoo JN, Mai le Q, Kawaoka Y, Osorio JE. Effects of route and coadministration of recombinant raccoon poxviruses on immune responses and protection against highly pathogenic avian influenza in mice. Vaccine. 2012; 30(45); 6402-6408. [PubMed: 22921740].