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Vaccine Detail

PAV3-HA (H5N1)
Vaccine Information
  • Vaccine Name: PAV3-HA (H5N1)
  • Target Pathogen: Influenza virus
  • Target Disease: Influenza (flu)
  • Vaccine Ontology ID: VO_0004695
  • Type: Recombinant vector vaccine
  • Status: Research
  • Host Species for Licensed Use: Baboon
  • Vector: porcine adenovirus 3 vaccine vector
  • Preparation: Replication-incompetent porcine adenovirus 3 (PAV3) vector (Patel et al., 2010).
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Mouse Response

  • Vaccination Protocol: Mice were vaccinated with different doses of the PAV3 vector expressing an optimized A/Hanoi/30408/2005 H5N1 hemagglutinin antigen (PAV3-HA) and compared with an AdHu5-HA contro (Patel et al., 2010).
  • Vaccine Immune Response Type: VO_0003057
  • Challenge Protocol: Mice were challenged with a lethal dose of H5N1-H05 virus (Patel et al., 2010).
  • Efficacy: The PAV3-HA vaccine, demonstrated improved survival and lower virus load. Evaluation of long-term vaccine efficacy at 12 months post-vaccination showed better protection with the PAV3-HA than with the AdHu5-HA vaccine (Patel et al., 2010).
References
Patel et al., 2010: Patel A, Tikoo S, Kobinger G. A porcine adenovirus with low human seroprevalence is a promising alternative vaccine vector to human adenovirus 5 in an H5N1 virus disease model. PloS one. 2010; 5(12); e15301. [PubMed: 21179494].