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Vaccine Detail
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PAV3-HA (H5N1) |
| Vaccine Information |
- Vaccine Name: PAV3-HA (H5N1)
- Target Pathogen: Influenza virus
- Target Disease: Influenza (flu)
- Vaccine Ontology ID: VO_0004695
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Baboon
- Vector:
- Preparation: Replication-incompetent porcine adenovirus 3 (PAV3) vector (Patel et al., 2010).
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccination Protocol: Mice were vaccinated with different doses of the PAV3 vector expressing an optimized A/Hanoi/30408/2005 H5N1 hemagglutinin antigen (PAV3-HA) and compared with an AdHu5-HA contro (Patel et al., 2010).
- Vaccine Immune Response Type: VO_0003057
- Challenge Protocol: Mice were challenged with a lethal dose of H5N1-H05 virus (Patel et al., 2010).
- Efficacy: The PAV3-HA vaccine, demonstrated improved survival and lower virus load. Evaluation of long-term vaccine efficacy at 12 months post-vaccination showed better protection with the PAV3-HA than with the AdHu5-HA vaccine (Patel et al., 2010).
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| References |
Patel et al., 2010: Patel A, Tikoo S, Kobinger G. A porcine adenovirus with low human seroprevalence is a promising alternative vaccine vector to human adenovirus 5 in an H5N1 virus disease model. PloS one. 2010; 5(12); e15301. [PubMed: 21179494].
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