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Vaccine Detail

Typhi strain Ty21a-PA (Bacillus anthracis)
Vaccine Information
  • Vaccine Name: Typhi strain Ty21a-PA (Bacillus anthracis)
  • Target Pathogen: Bacillus anthracis
  • Target Disease: Anthrax
  • Vaccine Ontology ID: VO_0004702
  • Type: Recombinant vector vaccine
  • Status: Research
  • Host Species for Licensed Use: Mouse
  • Vector: Salmonella typhi vaccine vector
  • Preparation: Anthrax protective antigen was delivered by Salmonella enterica serovar Typhi Ty21a (Osorio et al., 2009)
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Mouse Response

  • Vaccination Protocol: Control mice received three doses of Ty21a alone. Mice that were immunized i.n. received 5 × 108 CFU per dose, and mice that were immunized i.p. received 5 × 107 CFU per dose. i.n. immunization was performed by administering 20 μl of a bacterial solution to the nares (Osorio et al., 2009).
  • Vaccine Immune Response Type: VO_0003057
  • Challenge Protocol: Mice were exposed for 90 min to aerosolized spores (5 × 109 spores per ml in deionized water with 0.01% Tween 80) prepared from B. anthracis strain 7702(pXO1+, pXO2−) (Osorio et al., 2009).
  • Efficacy: Vaccinated mice demonstrated 100% protection against a lethal intranasal challenge with aerosolized spores of B. anthracis 7702 (Osorio et al., 2009).
References
Osorio et al., 2009: Osorio M, Wu Y, Singh S, Merkel TJ, Bhattacharyya S, Blake MS, Kopecko DJ. Anthrax protective antigen delivered by Salmonella enterica serovar Typhi Ty21a protects mice from a lethal anthrax spore challenge. Infection and immunity. 2009; 77(4); 1475-1482. [PubMed: 19179420].