• Vaccine Name: Typhi strain Ty21a-PA (Bacillus anthracis)
• Target Pathogen: Bacillus anthracis
• Target Disease: Anthrax
• Vaccine Ontology ID: VO_0004702
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Mouse
• Vector:
  • Vector name:
  • VO vector ID: VO_0001075
• Preparation: Anthrax protective antigen was delivered by Salmonella enterica serovar Typhi Ty21a (Osorio et al., 2009)
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccination Protocol: Control mice received three doses of Ty21a alone. Mice that were immunized i.n. received 5 × 10^8 CFU per dose, and mice that were immunized i.p. received 5 × 10^7 CFU per dose. i.n. immunization was performed by administering 20 μl of a bacterial solution to the nares (Osorio et al., 2009).
• Vaccine Immune Response Type: VO_0003057
• Challenge Protocol: Mice were exposed for 90 min to aerosolized spores (5 × 10^9 spores per ml in deionized water with 0.01% Tween 80) prepared from B. anthracis strain 7702(pXO1+, pXO2−) (Osorio et al., 2009).
• Efficacy: Vaccinated mice demonstrated 100% protection against a lethal intranasal challenge with aerosolized spores of B. anthracis 7702 (Osorio et al., 2009).