• Vaccine Name: Ty21a-O-Ps (Shigella dysenteriae )
• Target Pathogen: Shigella
• Target Disease: Shigellosis
• Vaccine Ontology ID: VO_0004703
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Baboon
• Vector:
  • Vector name:
  • VO vector ID: VO_0001075
  • Description: (Xu et al., 2007)
• Preparation: A tandemly-linked rfb-rfp gene cassette was cloned into low copy plasmid pGB2 to create pSd1 (Xu et al., 2007).
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccination Protocol: Groups of 10 mice were inoculated intraperitoneally with one or two 0.5 ml doses of either vaccine suspension or sterile PBS (Xu et al., 2007).
• Vaccine Immune Response Type: VO_0003057
• Challenge Protocol: Immunized and control mice were challenged 5 weeks after immunization with a lethal dose of 7.5 × 10^5 cfu of the freshly grown, mid-log phase virulent S. dysenteriae 1 stxA-deleted strain (1617Δ stxA) in 0.5 ml of 5% hog gastric mucin (Sigma) in sterile PBS (Xu et al., 2007).
• Efficacy: Animal immunization studies showed that Ty21a (pSd1) induces protective immunity against high stringency challenge with virulent S. dysenteriae 1 strain 1617 (Xu et al., 2007).