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Vaccine Detail

Ty21a-O-Ps (Shigella dysenteriae )
Vaccine Information
  • Vaccine Name: Ty21a-O-Ps (Shigella dysenteriae )
  • Target Pathogen: Shigella
  • Target Disease: Shigellosis
  • Vaccine Ontology ID: VO_0004703
  • Type: Recombinant vector vaccine
  • Status: Research
  • Host Species for Licensed Use: Baboon
  • Vector: Salmonella typhi vaccine vector
  • Preparation: A tandemly-linked rfb-rfp gene cassette was cloned into low copy plasmid pGB2 to create pSd1 (Xu et al., 2007).
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Mouse Response

  • Vaccination Protocol: Groups of 10 mice were inoculated intraperitoneally with one or two 0.5 ml doses of either vaccine suspension or sterile PBS (Xu et al., 2007).
  • Vaccine Immune Response Type: VO_0003057
  • Challenge Protocol: Immunized and control mice were challenged 5 weeks after immunization with a lethal dose of 7.5 × 105 cfu of the freshly grown, mid-log phase virulent S. dysenteriae 1 stxA-deleted strain (1617Δ stxA) in 0.5 ml of 5% hog gastric mucin (Sigma) in sterile PBS (Xu et al., 2007).
  • Efficacy: Animal immunization studies showed that Ty21a (pSd1) induces protective immunity against high stringency challenge with virulent S. dysenteriae 1 strain 1617 (Xu et al., 2007).
References